Volumetric analysis of bone substitute material performance within the human sinus cavity of former head and neck cancer patients: A prospective, randomized clinical trial
Identifieur interne : 000412 ( Main/Exploration ); précédent : 000411; suivant : 000413Volumetric analysis of bone substitute material performance within the human sinus cavity of former head and neck cancer patients: A prospective, randomized clinical trial
Auteurs : Jonas Lorenz [Allemagne] ; Kathrin Eichler [Allemagne] ; Mike Barbeck [Allemagne] ; Henriette Lerner [Allemagne] ; Stefan Stübinger [Suisse] ; Catherine Seipel [Allemagne] ; Thomas J. Vogl [Allemagne] ; Adorján F. Kovács [Allemagne] ; Shahram Ghanaati [Allemagne] ; Robert A. Sader [Allemagne]Source :
- Annals of Maxillofacial Surgery [ 2231-0746 ] ; 2016.
Abstract
In numerous animal and human studies, it could be detected that in bone augmentation procedures, material's physicochemical characteristics can influence the cellular inflammatory pattern and therefore the integration in the host tissue. Histological, histomorphometrical, and clinical analyses of the integration of the biomaterial in the surrounding tissue are well established methodologies; however, they do not make a statement on volume and density changes of the augmented biomaterial.
The aim of the present study was to assess the volume and density of a xenogeneic (Bio-Oss®, BO) and a synthetic (NanoBone®, NB) bone substitute material in split-mouth sinus augmentations in former tumor patients to complete histological and histomorphometrical assessment.
Immediately and 6 months after sinus augmentation computed tomography scans were recorded, bone grafts were marked, and the volume was calculated with radiologic RIS-PACS software (General Electric Healthcare, Chalfont St. Giles, Great Britain) to determine the integration and degradation behavior of both biomaterials.
Radiographic analysis revealed a volume reduction of the initial augmented bone substitute material (i.e. 100%) to 77.36 (±11.68) % in the BO-group, respectively, 75.82 (±22.28) % in the NB-group six months after augmentation. In both materials, the volume reduction was not significant. Bone density significantly increased in both groups.
The presented radiological investigation presents a favorable method to obtain clinically relevant information concerning the integration and degradation behavior of bone substitute materials.
Url:
DOI: 10.4103/2231-0746.200344
PubMed: 28299254
PubMed Central: 5343624
Affiliations:
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Vogl</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department for Diagnostic and Interventional Radiology, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Diagnostic and Interventional Radiology, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Kovacs, Adorjan F" sort="Kovacs, Adorjan F" uniqKey="Kovacs A" first="Adorján F." last="Kovács">Adorján F. Kovács</name><affiliation wicri:level="1"><nlm:aff id="aff4">Private Practice, Nauheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Private Practice, Nauheim</wicri:regionArea><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion></affiliation></author><author><name sortKey="Ghanaati, Shahram" sort="Ghanaati, Shahram" uniqKey="Ghanaati S" first="Shahram" last="Ghanaati">Shahram Ghanaati</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Sader, Robert A" sort="Sader, Robert A" uniqKey="Sader R" first="Robert A." last="Sader">Robert A. 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and neck cancer patients: A prospective, randomized clinical trial</title><author><name sortKey="Lorenz, Jonas" sort="Lorenz, Jonas" uniqKey="Lorenz J" first="Jonas" last="Lorenz">Jonas Lorenz</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Eichler, Kathrin" sort="Eichler, Kathrin" uniqKey="Eichler K" first="Kathrin" last="Eichler">Kathrin Eichler</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department for Diagnostic and Interventional Radiology, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Diagnostic and Interventional Radiology, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Barbeck, Mike" sort="Barbeck, Mike" uniqKey="Barbeck M" first="Mike" last="Barbeck">Mike Barbeck</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Lerner, Henriette" sort="Lerner, Henriette" uniqKey="Lerner H" first="Henriette" last="Lerner">Henriette Lerner</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Stubinger, Stefan" sort="Stubinger, Stefan" uniqKey="Stubinger S" first="Stefan" last="Stübinger">Stefan Stübinger</name><affiliation wicri:level="1"><nlm:aff id="aff3">Hightech Research Center of Cranio-Maxillofacial Surgery, University of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Hightech Research Center of Cranio-Maxillofacial Surgery, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Seipel, Catherine" sort="Seipel, Catherine" uniqKey="Seipel C" first="Catherine" last="Seipel">Catherine Seipel</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Vogl, Thomas J" sort="Vogl, Thomas J" uniqKey="Vogl T" first="Thomas J." last="Vogl">Thomas J. Vogl</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department for Diagnostic and Interventional Radiology, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Diagnostic and Interventional Radiology, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Kovacs, Adorjan F" sort="Kovacs, Adorjan F" uniqKey="Kovacs A" first="Adorján F." last="Kovács">Adorján F. Kovács</name><affiliation wicri:level="1"><nlm:aff id="aff4">Private Practice, Nauheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Private Practice, Nauheim</wicri:regionArea><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion></affiliation></author><author><name sortKey="Ghanaati, Shahram" sort="Ghanaati, Shahram" uniqKey="Ghanaati S" first="Shahram" last="Ghanaati">Shahram Ghanaati</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Sader, Robert A" sort="Sader, Robert A" uniqKey="Sader R" first="Robert A." last="Sader">Robert A. Sader</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of Maxillofacial Surgery</title><idno type="ISSN">2231-0746</idno><idno type="eISSN">2249-3816</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>In numerous animal and human studies, it could be detected that in bone augmentation procedures, material's physicochemical characteristics can influence the cellular inflammatory pattern and therefore the integration in the host tissue. Histological, histomorphometrical, and clinical analyses of the integration of the biomaterial in the surrounding tissue are well established methodologies; however, they do not make a statement on volume and density changes of the augmented biomaterial.</p></sec><sec id="st2"><title>Aims:</title><p>The aim of the present study was to assess the volume and density of a xenogeneic (Bio-Oss<sup>®</sup>, BO) and a synthetic (NanoBone<sup>®</sup>, NB) bone substitute material in split-mouth sinus augmentations in former tumor patients to complete histological and histomorphometrical assessment.</p></sec><sec id="st3"><title>Methods:</title><p>Immediately and 6 months after sinus augmentation computed tomography scans were recorded, bone grafts were marked, and the volume was calculated with radiologic RIS-PACS software (General Electric Healthcare, Chalfont St. Giles, Great Britain) to determine the integration and degradation behavior of both biomaterials.</p></sec><sec id="st4"><title>Results:</title><p>Radiographic analysis revealed a volume reduction of the initial augmented bone substitute material (i.e. 100%) to 77.36 (±11.68) % in the BO-group, respectively, 75.82 (±22.28) % in the NB-group six months after augmentation. In both materials, the volume reduction was not significant. Bone density significantly increased in both groups.</p></sec><sec id="st5"><title>Conclusion:</title><p>The presented radiological investigation presents a favorable method to obtain clinically relevant information concerning the integration and degradation behavior of bone substitute materials.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Lorenz, J" uniqKey="Lorenz J">J Lorenz</name></author><author><name sortKey="Stuebinger, S" uniqKey="Stuebinger S">S Stuebinger</name></author><author><name sortKey="Seitz, O" uniqKey="Seitz O">O Seitz</name></author><author><name sortKey="Landes, C" uniqKey="Landes C">C Landes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovacs, Af" uniqKey="Kovacs A">AF 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Barbeck</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Thimm, B" uniqKey="Thimm B">B Thimm</name></author><author><name sortKey="Stuebinger, S" uniqKey="Stuebinger S">S Stuebinger</name></author><author><name sortKey="Korzinskas, T" uniqKey="Korzinskas T">T Korzinskas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schlee, M" uniqKey="Schlee M">M Schlee</name></author><author><name sortKey="Dehner, Jf" uniqKey="Dehner J">JF Dehner</name></author><author><name sortKey="Baukloh, K" uniqKey="Baukloh K">K Baukloh</name></author><author><name sortKey="Happe, A" uniqKey="Happe A">A Happe</name></author><author><name sortKey="Seitz, O" uniqKey="Seitz O">O Seitz</name></author><author><name sortKey="Sader, R" uniqKey="Sader R">R Sader</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eppley, Bl" uniqKey="Eppley B">BL Eppley</name></author><author><name sortKey="Pietrzak, Ws" uniqKey="Pietrzak W">WS Pietrzak</name></author><author><name sortKey="Blanton, Mw" uniqKey="Blanton M">MW Blanton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoexter, Dl" uniqKey="Hoexter D">DL Hoexter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Orth, C" uniqKey="Orth C">C Orth</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Thimm, Bw" uniqKey="Thimm B">BW Thimm</name></author><author><name sortKey="Booms, P" uniqKey="Booms P">P Booms</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerber, T" uniqKey="Gerber T">T Gerber</name></author><author><name sortKey="Traykova, T" uniqKey="Traykova T">T Traykova</name></author><author><name sortKey="Henkel, Ko" uniqKey="Henkel K">KO Henkel</name></author><author><name sortKey="Bienengraeber, V" uniqKey="Bienengraeber V">V Bienengraeber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerike, W" uniqKey="Gerike W">W Gerike</name></author><author><name sortKey="Bienengr Ber, V" uniqKey="Bienengr Ber V">V Bienengräber</name></author><author><name sortKey="Henkel, Ko" uniqKey="Henkel K">KO Henkel</name></author><author><name sortKey="Bayerlein, T" uniqKey="Bayerlein T">T Bayerlein</name></author><author><name sortKey="Proff, P" uniqKey="Proff P">P Proff</name></author><author><name sortKey="Gedrange, T" uniqKey="Gedrange T">T Gedrange</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jensen, Ss" uniqKey="Jensen S">SS Jensen</name></author><author><name sortKey="Aaboe, M" uniqKey="Aaboe M">M Aaboe</name></author><author><name sortKey="Pinholt, Em" uniqKey="Pinholt E">EM Pinholt</name></author><author><name sortKey="Hj Rting Hansen, E" uniqKey="Hj Rting Hansen E">E Hjørting-Hansen</name></author><author><name sortKey="Melsen, F" uniqKey="Melsen F">F Melsen</name></author><author><name sortKey="Ruyter, Ie" uniqKey="Ruyter I">IE Ruyter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norton, Mr" uniqKey="Norton M">MR Norton</name></author><author><name sortKey="Odell, Ew" uniqKey="Odell E">EW Odell</name></author><author><name sortKey="Thompson, Id" uniqKey="Thompson I">ID Thompson</name></author><author><name sortKey="Cook, Rj" uniqKey="Cook R">RJ Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorenz, J" uniqKey="Lorenz J">J Lorenz</name></author><author><name sortKey="Kubesch, A" uniqKey="Kubesch A">A Kubesch</name></author><author><name sortKey="Korzinskas, T" uniqKey="Korzinskas T">T Korzinskas</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Landes, C" uniqKey="Landes C">C Landes</name></author><author><name sortKey="Sader, Ra" uniqKey="Sader R">RA Sader</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Lorenz, Jonas" sort="Lorenz, Jonas" uniqKey="Lorenz J" first="Jonas" last="Lorenz">Jonas Lorenz</name></region><name sortKey="Barbeck, Mike" sort="Barbeck, Mike" uniqKey="Barbeck M" first="Mike" last="Barbeck">Mike Barbeck</name><name sortKey="Eichler, Kathrin" sort="Eichler, Kathrin" uniqKey="Eichler K" first="Kathrin" last="Eichler">Kathrin Eichler</name><name sortKey="Ghanaati, Shahram" sort="Ghanaati, Shahram" uniqKey="Ghanaati S" first="Shahram" last="Ghanaati">Shahram Ghanaati</name><name sortKey="Kovacs, Adorjan F" sort="Kovacs, Adorjan F" uniqKey="Kovacs A" first="Adorján F." last="Kovács">Adorján F. Kovács</name><name sortKey="Lerner, Henriette" sort="Lerner, Henriette" uniqKey="Lerner H" first="Henriette" last="Lerner">Henriette Lerner</name><name sortKey="Sader, Robert A" sort="Sader, Robert A" uniqKey="Sader R" first="Robert A." last="Sader">Robert A. Sader</name><name sortKey="Seipel, Catherine" sort="Seipel, Catherine" uniqKey="Seipel C" first="Catherine" last="Seipel">Catherine Seipel</name><name sortKey="Vogl, Thomas J" sort="Vogl, Thomas J" uniqKey="Vogl T" first="Thomas J." last="Vogl">Thomas J. Vogl</name></country><country name="Suisse"><noRegion><name sortKey="Stubinger, Stefan" sort="Stubinger, Stefan" uniqKey="Stubinger S" first="Stefan" last="Stübinger">Stefan Stübinger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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